Men's Diseases and Conditions

Medications and Substances that can have a negative impact on your sex life

As men and women get older and more medical problems arise necessitating more medications be taken to fix these problems. Unfortunately the side effects for most prescription medications, and even over the counter medications, are usually extensive. Side effects range from physical, mental, emotional, and can even be life threatening! Additionally one’s sex life can even be affected due to one, or many, of the negative side effects from medications!

If you find yourself incapable of maintaining your erection, or just not as interested in sex as you used to be, then instead of “just dealing with it” you need to open up your medicine cabinet and take a look at some of the pill bottles! You’ll be surprised to see how many medications you are taking can have an effect on your manhood (or womanhood!) however some of the medications don’t even list some sexual disturbances on their labels!

To help you understand which medications may be interfering with your love life check the list below for most of the common medications prescribed (and OTC) and find out which ones may be ruining the mood for you!

Medication Name

General Use

Possible sexual side effects

Amitryptiline Depression Low sex drive,  difficult or no orgasm, problems ejaculating
Atenolol High BP, Angina Impotence
Bendroflumethiazide High BP Impotence
Beta blockers Angina, High BP, Migraines Low sex drive
Busulfan Cancer Erectile Dysfunction
Carbamazepine Seizures, Epilepsy Impotence
Cimetidine Ulcers, acid reflux Low sex drive, impotence
Clofibrate Lower high cholesterol impotence
Clonidine High BP Low sex drive, impotence
Cyclobenzaprine Muscle spasms, muscle pain Erectile dysfunction
Cyproterone acetate Prostate cancer Low sex drive, impotence, lowered ejaculation amount
Disulfiram Treat alcohol withdrawal symptoms Low sex drive
Doxazosin Enlarged Prostate Problems ejaculating
Enalapril High BP and other heart problems Impotence
Finasteride Enlarged prostate Low sex drive, lowered amount of ejaculate, impotence
Fluoxetine Depression Low sex drive,  difficult or no orgasm, problems ejaculating
Gemfibrozil Lower high cholesterol impotence
Lisinopril High BP and other heart problems Impotence
Methyldopa High BP Low sex drive, impotence
Moclobemide Depression Low sex drive,  difficult or no orgasm, problems ejaculating
Morphine Pain Low sex drive, impotence
Nifedipine High BP, Angina Impotence
Orphenadrine Muscle spasms, Muscle pain Erectile Dysfunction
Prazosin Large prostate or high BP Impotence, problems ejaculating
Phenelzine Depression Low sex drive,  difficult or no orgasm, problems ejaculating
Risperidone Bipolar disorder, schizophrenia, and schizoaffective disorder Impotence, problems ejaculating
Simvastatin Lower high cholesterol impotence
Spironolactone CHF, Fluid retention, cirrhosis Low sex drive, impotence
Thioridazine Schizophrenia, Psychosis Low sex drive, impotence, problems ejaculating
Timolol eye drops Glaucoma Impotence
Trazodone Depression Orgasmic dysfunction
Tricyclic antidepressants Antidepressant Low sex drive
Verapamil Angina, High BP Impotence

If you are experiencing sexual disturbances and you aren’t taking any of the above medications then there are many other substances that can cause these symptoms such as:

  • Alcohol
  • Cocaine
  • Marijuana
  • Meth
  • Opiates
  • Cigarettes, chew, and any other substances with nicotine

Common medication alternatives for certain conditions

High Blood Pressure

Many of the high blood pressure medications have the potential to negatively affect sexual performance however there are a variety of different medications available to help treat your high blood pressure. If you are experiencing issues then talk to your doctor about an ACE inhibitor like enalapril or see if you can take alpha-blockers as opposed to water tablets or even beta-blockers.


Since many of the depression medications work to help stabilize the hormones in the brain they also have the potential to affect a variety of other things as well including your sex life. If you are taking depression medications then you should know that SSRI’s (selective serotonin reuptake inhibitor) then speak with your doctor about your symptoms because SSRI’s are well known for causing sexual problems and your doctor may be able to prescribe you an alternative such as a MAOI or some other antidepressant.

What should you do if your medications are affecting your sex life?

If you noticed a decline in your sexual performance that correlated with the start of a new medication then you should not hesitate to contact your physician immediately and go in for evaluation. Before going in to speak with your doctor you should NEVER stop using the medications unless you are experiencing life threatening side effects or you consult him/her first. Sometimes your doctor may not even have to see you to order an alternative medication – though this may not always be the case.

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Author: Peter

Peter is an experienced author specializing in men's health issues. He started in 2007 and is dedicated to continue to grow the website to become a recognized resource for men worldwide.